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Wheat and Gluten Reactivity & Autoimmunity test- Cyrex Array 3x

Wheat and Gluten Reactivity & Autoimmunity test- Cyrex Array 3x

This Wheat and gluten test can aid in identifying Wheat and Gluten Reactivity, and measures antibody production against 8 wheat proteins and peptides and 3 essential enzymes.

When the NHS test you for celiac they are only looking for tissue tranglutaminase  – missing out many possible reactions.

This is one of the most comprehensive panels available for establishing which component of the wheat protein challenges your immune system therefore producing antibodies as a response. With the inclusion of opioid peptides, which have been linked to symptoms such as ‘brain fog’, behavioural problems, mood swings, depression, or other neurological complaints, a clearer picture can be created in terms of identifying what the underlying causes are of related symptoms. It also includes various tissue transglutaminases, which indicate tissue damage to various tissues in the body including neural tissue.

Recommended if you:

  • Have non-responsive gastrointestinal symptoms
  • Present multiple-symptom complaints (including Chronic Fatigue Syndrome and Fibromyalgia)
  • Suffer from depression or neuro-autoimmunity

A gluten-free diet can cause false negative results on gluten protein/peptide tests.

Before Taking A CYREX Test

While Cyrex is unable to provide an exhaustive list of medications due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

a. Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
b. Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
c. Inhalers can affect the results of Cyrex’s oral fluid testing (Array 1). Wait two weeks after completion of inhalant dosages before collecting the specimen.
d. Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex has already developed Array 4 in order to recognize the most common antigens in this regard.
e. A gluten-free diet can cause false negative results on gluten protein/peptide tests.
f. Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.1



What is being measured – IgG and IgA of:

  • Wheat
  • Wheat Germ Agglutinin
  • Native + Deamidated Alpha-Gliadin-33-mer
  • Alpha-Gliadin-17-mer
  • Gamma-Gliadin-15-mer
  • Gamma-Gliadin-17-mer
  • Glutenin-21-mer
  • Gluteomorphin + Prodynorphin
  • Gliadin-Transglutaminase Complex
  • Transglutaminase-2
  • Transglutaminase-3
  • Transglutaminase-6

Specimen requirements

Blood test that requires a blood sample. The blood sample will need to be centrifuged.

You can attend a laboratory in London to have the sample taken or you will need to arrange for a blood sample to be collected by a nurse at your G.P. service or at a private clinic or hospital. Any fee for this service is not included in with the test fee.

Returning your sample

You will need to send your sample back to the lab via a next day postal service – If you are in the UK, Royal mail offer a suitable next day service. If you are outside of the UK then please check with your postal service for options. The cost of the test does not cover the return postage.

Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.

Turnaround time

14 -21 days.

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Please note – It is VERY important that your sample is returned the same day either by using the Royal Mail or courier service which guarantees delivery by 1pm or by using the UPS service provided with the sample kit. If you decide to use the UPS service, there is an additional charge of £9.00.

Where can I arrange a blood draw?