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Multiple Autoimmune Reactivity Screen – Cyrex Array 5

Multiple Autoimmune Reactivity Screen – Cyrex Array 5

The Multiple Autominnue reactivity test checks for the production of predictive autoantibodies which are the initial sign in the development of autoimmune conditions. Some of the autoantibodies can appear up to 10 years before any clinical symptom so identifying them before a condition is diagnosed could reduce extensive tissue damage.

What are autoantibodies? – The immune system produces antibodies to allow the body to differentiate between ‘self’ and ‘non-self’ tissues. Autoantibodies target and cause damage to specific tissues or organs of the body.

Recommended if you:

  • Have a diagnosed autoimmune disorder, as there is a 25% chance of developing another condition
  • Have chronic increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders

What is being measured – IgG and IgA of:

  • Parietal Cell and ATPase
  • Intrinsic Factor
  • ASCA and ANCA
  • Tropomyosin
  • Thyroglobulin
  • Thyroid Peroxidase (TPO)
  • 21 Hydroxylase (Adrenal Cortex)
  • Myocardial Peptide
  • Alpha-Myosin
  • Phospholipid
  • Platelet Glycoprotein
  • Ovary/Testies
  • Fibulin
  • Collagen Complex
  • Arthritic Peptide
  • Osteocyte
  • Cytochrome P450 (Hepatocyte)
  • Insulin and Islet Cell Antigen
  • Glutamic Acid Decarboxylase 65 (GAD 65)
  • Myelin Basic Protein
  • Asialoganglioside
  • Alpha and Beta Tubulin
  • Cerebellar
  • Synapsin

Before Taking A CYREX Test

While Cyrex is unable to provide an exhaustive list of medications due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

a. Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
b. Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
c. Inhalers can affect the results of Cyrex’s oral fluid testing (Array 1). Wait two weeks after completion of inhalant dosages before collecting the specimen.
d. Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex has already developed Array 4 in order to recognize the most common antigens in this regard.
e. A gluten-free diet can cause false negative results on gluten protein/peptide tests.
f. Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.1



Specimen requirements

Blood test that requires a blood sample. The blood sample will need to be centrifuged.

You can attend one of two laboratories in London to have the sample taken or you will need to arrange for a blood sample to be collected by a nurse at your G.P. service or at a private clinic or hospital. Any fee for this service is not included in with the test fee.

Where can I arrange a blood draw?

Returning your sample

You will need to send your sample back to the lab via a next day postal service – If you are in the UK, Royal mail offer a suitable next day service. If you are outside of the UK then please check with your postal service for options. The cost of the test does not cover the return postage.

Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.

Turnaround time

14 -21 days.