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Oestrogen Metabolism

Oestrogen Metabolism

The Oestrogen Metabolism Assessment evaluates how estrogen is being processed in the body. A balance of anti and pro carcinogenic breakdown products of oestrogen are assessed and can shed light into many oestrogen-dependent conditions and provides an important tool for monitoring dietary, lifestyle and hormone therapies.

Might I benefit from this test?

If you have a family history of hormonal cancers such as Breast and Uterine cancer or if you have a history of oestrogen dominance which can result in conditions such as PMS, fibroids and endometriosis then this test could be of value to you.

The potential impact of estrogen on a person’s health and well-being is enormous.

Oestrogen can exert a strong influence in diverse conditions such as

  • Breast cancer
  • Prostate cancer
  • Osteoporosis
  • Heart disease
  • Autoimmune disorders

Oestrogen Metabolism

Oestrogen metabolites provide valuable clinical information regarding cancer risk. Two significant metabolites (break down products) that can be accurately assessed are 16 alpha-hydroxyestrone

(16 alpha-OHE1) and 2-hydroxyestrone (2-OHE1).

• 16 alpha-OHE1 is a powerful metabolite that stimulates target tissues. Levels can rise in response to obesity, alcohol consumption, and toxic exposure. High levels of this potent metabolite are linked to increased risk and poorer prognosis in conditions linked to estrogen excess such as breast cancer and lupus.

2-OHE1 is a metabolite that binds weakly to cell receptors and may slow cell proliferation. Excessive levels of 2-OHE1 may increase the risk of osteoporosis in post-menopausal women with low oestrogen.

The all Important Ratio

The ratio between 2-OHE1 and 16 alpha-OHE1 is the key to optimizing health.

Treatments that increase the 2:16 alpha-OHE1 ratio help to reduce the risk of estrogen dependent disease enabling correct dietary and supplemental choices and monitoring. The Estrogen Metabolism Assessment is designed for both premenopausal and postmenopausal women.

What is being measured

  • Creatinine
  • 2-OHE1, 16a-OHE1,
  • 2-OHE1/16a-OHE1 ratio

Age range this test is suitable for

Adults 18+

Specimen Requirements

Urine—10ml first morning urine sample.

You will need to send your sample back to the lab via a next day postal service – If you are in the UK, Royal mail offer a suitable next day service. If you are outside of the UK then please check with your postal service for options. The cost of the test does not cover the return postage.
Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.
A courier returns option is offered by the lab and details will be included in with your test kit. This is an optional service and the cost is not included in with the test fee. Details about payment, should you wish to take up this offer, are included with the courier details.

Before Taking This Test

Premenstrual women: Collect the sample between days 18 and 25 of menstrual cycle

Women on HRT or oral contraceptives: Collect sample 8-10 hours after last dose

Urine: Patients should have normal kidney and urinary tract functions

Urine: Inform practitioner of diuretic use or excessive fluid intake

Schedule sample collection for Monday through Thursday

See instructions inside test kit for details

Turnaround Time

24 Days

 

All sample reports are for representational and educational purposes only. Biomarkers, references ranges, results, and all other data may differ from actual reports. All data included in no way represents an actual patient. Any comparisons of results to actual patients, is completely incidental.

Smart Nutrition Oestrogen Metabolism Sample Report

Turnaround Time

25 days

All sample reports are for representational and educational purposes only. Biomarkers, references ranges, results, and all other data may differ from actual reports. All data included in no way represents an actual patient. Any comparisons of results to actual patients, is completely incidental.

Smart Nutrition Oestrogen Metabolism Plus Sample Report

European Orders

Test kits can be sent out to Europe however  you will be responsible  for returning the test kit and this should arrive at the lab no later than 24 hours after the sample has been taken for delivery on monday, tuesday, wednesday or thursday only.

European Orders – Courier Delivery

Test kits can be sent out to Europe via our courier sevice however there is an additional fee added if you would like to use this service. You will be responsible  for returning the test kit and this should arrive at the lab no later than 24 hours after the sample has been taken for delivery on monday, tuesday, wednesday or thursday only.