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EstroGenomic Profile

EstroGenomic Profile

Oestrogen Metabolism

The metabolism of oestrogen is an important process that involves phase 1 and 2 enzymes of the liver which are responsible for the formation of pro- and anti-carcinogenic metabolites as well as their removal. Raised levels of these metabolites could be indicated in an increased risk of breast cancer and osteoporosis.

Coagulation

Variations and mutations of genes that are responsible for the interaction of  oestrogen with clot formation and fibrinolysis process can over-activate blood clotting processes. Therefore increasing the risk of sudden cardiac events such as thrombosis, heart attacks, and strokes.

Cardiovascular

These genes affect how the body processes cholesterol, responds to inflammation, and metabolizes B vitamins. The presence of these SNPs can increase risk of cardiovascular disease, hyperlipidemia, and blood vessel damage.

This profile covers the genetic susceptibility to the following diseases and conditions:

  • Breast cancer
  • Osteoporosis
  • Thrombosis
  • Strokes
  • Atherosclerosis
  • Heart Disease

What is being measured

  • APOE (Apoliprotein E)
  • COMT (Catechol-O-Methyl Transferase)
  • CYP1A1 (Cytochrome P-450)
  • CYP1B1 (Cytochrome P-450)
  • Factor 2 (Prothrombin)
  • Factor 5 (Leiden)
  • GP3a (Glycoprotein 3)
  • GST (M1 and P1) (Glutahione s-Transferase)
  • IL-6 (Interleukin-6)
  • MTHFR (Methylenetetrahydrofolate Reductase)
  • PAI-1 (Plasminogen Activator Inhibitor-1)
  • TNF-a (Tumor Necrosis Factor-alpha)
  • VDR (Vitamin D3 receptor)

Age range this test is suitable for

Adults and children of any age

Specimen Requirement

Buccal – swab

You will need to send your sample back to the lab via a next day postal service – If you are in the UK, Royal mail offer a suitable next day service. If you are outside of the UK then please check with your postal service for options. The cost of the test does not cover the return postage.
Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.
A courier returns option is offered by the lab and details will be included in with your test kit. This is an optional service and the cost is not included in with the test fee. Details about payment, should you wish to take up this offer, are included with the courier details.

Before taking this test

The buccal swab is designed to collect some loose cells in your mouth. Brush your teeth the night before the test. Do not eat any food after you have brushed your teeth. Upon awakening for the day of collection, do not brush your teeth, eat or drink anything prior to the sample collection.

See instructions inside test kit for details

Turn Around Time

26 days

All sample reports are for representational and educational purposes only. Biomarkers, references ranges, results, and all other data may differ from actual reports. All data included in no way represents an actual patient. Any comparisons of results to actual patients, is completely incidental.

Smart Nutrition EstroGenomic Sample Report