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Methylation Panel

Methylation Panel

All About the Methylation Panel

What is Methylation?

Methylation is a chemical process that happens billions of times per second in every cell of the body. The process of methylation acts like billions of switches within the body – turning things on and off, influencing and changing things. Methyl groups that relate to methylation also help regulate mood, detoxify hormones, produce energy, and promote healthy aging.

The process of methylation requires vitamins, minerals, and amino acids from the diet to keep this process running smoothly. Genetic factors and oxidative stressors can also affect how well this pathway works.

Why is Methylation important?

Methylation is involved in basic energy production, fat metabolism, immune responses, vascular health, and cell membrane repair. It is needed to create DNA and RNA and regulate gene expression. Methylation helps make creatine, required for skeletal muscle contraction and it produces and metabolizes neurotransmitters to regulate mood. It also works to neutralize toxins and hormones.

Defects in Methylation have been associated with many clinical conditions including, but not limited to autism, ADHD, congenital and neural tube defects, cognitive decline, depression, cardiovascular disease, and schizophrenia.

Methylation has an all-encompassing role in basic human physiology, the range of symptoms associated with methylation defects is broad.

The Methylation Panel assesses the methylation cycle, and also incorporates the folate cycle and transsulfuration. Because these three processes are interconnected, the Methylation Panel is able to provide a complete picture regarding Methylation status.

What is being measured

Betaine/Choline Ratio
Met/Sulf Ratio
Methylation Balance Ratio
S-Adenosylhomocysteine (SAH)
S-Adenosylmethionine (SAM)

Age range this test is suitable for

Suitable for ages 18 +. Not suitable for children below 18 years old.

Specimen Requirements.

A Blood sample  – that requires centrifuging.
Samples must be received at the lab within 24 hours of the sample being taken.

You will need to send your sample back to the lab via a next day postal service to arrive within 24 hour of the sample having been drawn– If you are in the UK, Royal mail offer a suitable next day before 9 am or before 10 am service. If you are outside of the UK then please check with your postal service for options. The cost of the test does not cover the return postage.

Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.

A courier returns option is offered by the lab and details will be included in with your test kit. This is an optional service and the cost is not included in with the test fee. Details about payment, should you wish to take up this offer, are included with the courier details.

Before Taking the Test

An overnight fast is required prior to the blood sample being taken.
SAM-e supplementation and amino acid formulas may impact results.
Non essential vitamin supplements like Vitamin B should be discontinued for 4 days prior to the test.

Turnaround time

14 days.


Smart Nutrition Methylation Panel Sample Report

Please note that this sample report contains the genetic add ons which we can offer but you would need to call us to add these on until we have included them as an option on the website.

Download it here.