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Urinary Polypeptides

Urinary Polypeptides

This test analyses urine for diet-derived peptides (protein break down products) that may contribute to imbalances in conditions such as autism, ADD, ADHD, depression, and schizophrenia as total urinary peptides are globally associated with an increase in neurologic and psychiatric imbalances.

This test is temporarily unavailable due to administration issues. We hope to re-instate it shortly.

Foods and Autism

Parents have observed that certain foods appear to exacerbate symptoms of autism. It has been determined that symptoms particularly arise from proteins, including gluten (from wheat and other cereals) and casein (derived from milk). Some of the peptides obtained from gluten and casein are very similar to endorphins found in the brain and therefore have an effect.

Treatment options involve diet, supplementation and eradication of intestinal irritants.

The Effect of Intestinal Permeability

Polypeptides circulating in the bloodstream are found in the urine of children (and adults) with neuro-psychiatric problems. This can be a consequence of increased intestinal permeability, sometimes referred to as “leaky gut” which increases the passage of peptides through the gut and into the blood stream due to

  • Infection
  • Dysbiosis
  • Parasites
  • Yeast overgrowth
  • Food allergies
  • Nutritional deficiencies causing damage to the intestinal lining

A leaky gut test is also worth considering.

There are two basic types of urinary polypeptides measured

Gliadorphin (peptide from wheat)

Casomorphin (peptide from dairy)

What is Gliadorphin?

Gliadorphin (or gluteomorphin) is a peptide derived from the wheat protein gluten. Other related grains such as rye, barley and oats also contain the sequence of amino acids found in gluten. Gliadorphin is very similar to casomorphin. Gliadorphin has been verified by mass spectrometry techniques to be present in urine samples of children with autism.

What is Casomorphin?

Casomorphin is a peptide derived from the milk protein casein. Casein is one of the major proteins in the milk of all mammals including cows, goats, and humans


Specimen Requirements

10 mL of first morning urine before food and drink is preferred. The patient must discontinue soy proteins one week prior to collection of specimen (soy bean oil and soy lecithin are considered acceptable).

See instructions inside test kit for details

Before Taking this Test

Specimen must be collected Monday to Thursday

Turnaround time

21 days

This test is temporarily unavailable due to administration issues. We hope to re-instate it shortly.