Why Blood Testing Is Essential Alongside Methylation Genetics
Genetic testing offers valuable insight into how someone might process nutrients — but it doesn’t tell us what’s actually happening right now. Genes are like the blueprint or potential, but they don’t operate in isolation. As the saying goes: genetics loads the gun, but the environment pulls the trigger.
Someone may carry a slow MTHFR variant — but are they a 6-foot sumo wrestler with high nutrient demands, or a 4-foot-2, slightly built woman with a minimal intake and lower metabolic needs? A genetic report can’t tell us that. It also doesn’t reveal whether someone is living on fast food or following a nutrient-rich, balanced diet. Genes show us the potential — but they don’t show us the current reality.
That’s why, when it comes to making personalised, effective nutrition decisions — particularly around methylation — it’s essential to combine functional blood testing with genetic results.
When we look at methylation-related genes like MTHFR, MTR, MTRR, COMT, and others, we gain a better understanding of how a person might convert folate, process B12, recycle homocysteine, or clear neurotransmitters. But what we don’t see is:
That’s where blood testing becomes crucial. Measuring markers such as:
Put simply, genetics tells us what the body is capable of, but blood testing shows us what the body is actually doing.
Please note that if you plan to attend the central London lab, you must select the blood draw add-on below. If this is not selected, the kit will be sent to your home and the lab will not be prompted to contact you to arrange your blood draw appointment.
Defects in methylation are wide and varied and have been associated with many clinical conditions including, but not limited to:
Anxiety
Autism
ADHD
Autoimmune conditions
Bipolar disorder
Cancer
Cardiovascular disease
Chronic fatigue
Congenital and neural tube defects
Cognitive decline
Chronic fatigue
Depression
Cardiovascular disease
Inflammatory conditions
Infertility
Low energy
Neurotransmitter imbalance
Parkinson’s
Premature ageing
Schizophrenia
Active (Methylated) B12
Red blood cell (Methylated) Folate
Vitamin D
Zinc
Red blood cell Magnesium
Omega 3/6 ratio
Vitamin B6
Vitamin B2
Copper
Selenium
Iron
Ferritin
Homocysteine
The Methylation Essential Nutrients Comprehensive Blood Test requires a Blood sample.
Please note that if you plan to attend the central London lab, you must select the blood draw add-on below. If this is not selected, the kit will be sent to your home and the lab will not be prompted to contact you to arrange your blood draw appointment.
Please avoid all supplements that contain essential fats, vitamins and minerals for 48 hours prior to Methylation – Essential Nutrients Comprehensive Blood Test
Please check with your GP or healthcare practitioner that it is safe to stop any prescribed vitamins, minerals, or essential fatty acids such as fish oils before taking this test
The Methylation – Essential Nutrients Comprehensive Blood Test is suitable for Age 12 and above
Attending the lab in person
We recommend attending our lab in London because of the time sensitive nature of the samples.
The lab’s location is; 34 Great Titchfield St., London W1W 8BQ
Once the lab have received your order – via Smart Nutrition, the team at the lab will arrange the appointment for the blood collection with you directly.
The cost of the blood draw is £50 and is paid directly to the lab when you book.
Please note that if you plan to attend the central London lab, you must select the blood draw add-on below. If this is not selected, the kit will be sent to your home and the lab will not be prompted to contact you to arrange your blood draw appointment.
If you cannot attend the lab in London
The red blood cell folate cannot be posted.
The zinc will need to be centrifuged and separated to make it suitable to be posted back.
Homocysteine is time sensitive and needs centrifuging and processing/ separating and posting back straight away.
Next-day delivery postage and packaging is included for all orders that are not attending the lab in central London.
If you cannot attend the lab in person and choose to leave any of the above (such as the folate) out of the panel unfortunately you will still need to pay for the full panel.
It will take 10 Working days to get your Methylation – Essential Nutrients Comprehensive Blood Test
You will receive your Methylation – Essential Nutrients Comprehensive Blood Test results by email.
This sample report includes the bile acids and SCFA’s add on
All sample reports are for representational and educational purposes only. Biomarkers, references ranges, results, and all other data may differ from actual reports. All data included in no way represents an actual patient. Any comparisons of results to actual patients is completely incidental.
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Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.
The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.
