The Oxidative Stress Analysis Urine assesses lipid peroxides and 8-OHdG, two oxidative tissue damage markers. Oxidative stress underlies and contributes to many common chronic diseases and degenerative processes. The Oxidative Stress Urine test can highlight dietary and/or lifestyle changes you may need to make to stall oxidative damage.
Free radicals and antioxidants
In the course of normal human activity, processes such as energy production, detoxification of pollutants and immunologic defence mechanisms produce free radicals: unstable molecules that can extract an electron from a neighbouring molecule, causing damage in the process. Unchecked free radical production accelerates the pathogenesis of human disease and ageing. Free radicals are counter-balanced and kept in check by the antioxidants present in our foods (and, when necessary, supplements).
Dietary antioxidants such as proanthocyanidins (found in blueberries) and bioflavonoids (found in citrus fruits), as well as the antioxidant enzymes superoxide dismutase and glutathione peroxidase, provide critical protection against free radical damage.
When the delicate pro-oxidant/antioxidant equilibrium is disrupted in favour of the pro-oxidant (free radical) state, evidence is accumulating that oxidative stress is involved in many pathological processes, including:
A urine sample is used to measure free radical damage, including:
Lipid peroxides (oxidative damage to cell membranes).
8-hydroxy-deoxyGuanosine (oxidative damage to DNA).
Women should not collect the urine sample during menstruation.
Abnormal kidney function or use of diuretics may influence test results. Do not carry out this test if you have any form of kidney disorders. Abnormal kidney function or use of diuretics may influence test results.
Some medications may impact test results e.g. cephalosporins, cimetidine (Tagamet), fibrates (e.g. Ciprofibrate), and trimethoprim.
It is essential to avoid excessive fluid intake for the 24 hours prior to collection. Aim
to drink no more than an average fluid intake of 1.5 litres, spread throughout the day.
A freezer pack is included that needs to be placed in the freezer for a minimum of 4 hours.
The sample must be frozen for at least 2 hours prior to shipping. If you collect your sample on a Friday – Sunday it can be stored in the freezer until shipping collection on Monday.
2 years and above.
Please return via a next day service Monday – Thursday only. The sample must be stored in the freezer prior to returning.
A courier option is sent with your test kit. You pay the laboratory directly for this test and also the return courier if you use the service. You can also make your own arrangements for returning your samples via a next day service.
14 working days.
Your test results will be emailed to you.