Cyrex Array 5 Multiple Autoimmune Screen

Cyrex Array 5 Multiple Autoimmune Screen

The multiple autoimmune reactivity test checks for the production of predictive autoantibodies which are the initial sign in the development of autoimmune conditions. Some of the autoantibodies can appear up to 10 years before any clinical symptom so identifying them before a condition is diagnosed can reduce extensive tissue damage.


What are autoantibodies?

The immune system produces antibodies to allow the body to differentiate between ‘self’ and ‘non-self’ tissues. Autoantibodies target and cause damage to specific tissues or organs of the body.

This test is recommended if you:

  • Have a diagnosed autoimmune disorder, as there is a 25% chance of developing another condition.
  • Have chronic increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders.



Parietal cell + ATPase IgG + IgA combined
Intrinsic factor IgG + IgA combined
ASCA + ANCA IgG + IgA combined
Tropomyosin IgG + IgA combined
Thyroglobulin IgG
Thyroid peroxidase (TPO) IgG
21 hydroxylase (Adrenal Cortex) IgG + IgA combined
Myocardial peptide IgG + IgA combined
Alpha-myosin IgG + IgA combined
Phospholipid IgG + IgA combined
Platelet glycoprotein IgG + IgA combined
Ovary/Testis* IgG + IgA combined
Fibulin IgG + IgA combined
Collagen complex IgG + IgA combined
Arthritic peptide IgG + IgA combined
Osteocyte IgG + IgA combined
Cytochrome P450 (hepatocyte) IgG + IgA combined
Islet cell antigen (IA-2) autoantibody
Glutamic acid decarboxylase 65 (GAD 65) autoantibody
Myelin basic protein IgG + IgA combined
Asialoganglioside IgG + IgA combined
Alpha + beta tubulin IgG + IgA combined
Cerebellar IgG + IgA combined
Synapsin IgG + IgA combined

* Ovary and Testis are tested together to avoid any confusion
arising from potential cross-reactivity.

This is a blood test that requires a blood sample which will then need to be centrifuged. Centrifuge can be carried out at the lab if the sample is received within 24 hours from the blood draw.

You will need to arrange for a blood sample to be collected either at a laboratory in London, by a nurse at your GP service or at a private clinic or hospital. Any fee for this service is not included with the test fee.


While Cyrex is unable to provide an exhaustive list of medications due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

  • Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
  • Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
  • Inhalers can affect the results of Cyrex’s oral fluid testing (Array 1). Wait two weeks after completion of inhalant dosages before collecting the specimen.
  • Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex has already developed Array 4 in order to recognise the most common antigens in this regard.
  • A gluten-free diet can cause false negative results on gluten protein/peptide tests.
  • Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.

Please do not stop any medication without your doctor’s consent.

Once you’ve collected your sample, you’ll need to send it back to the lab via a next day service. A prepaid return label is included with your test kit.

Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.

3 years and above.

14-21 days.


Your test results will be emailed to you.

Cyrex Array 5 Multiple Autoimmune Screen


Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.