Cyrex Array 2 Leaky Gut

Cyrex Array 2 Leaky Gut

Leaky gut syndrome is also known as intestinal permeability.

A normal healthy gut lining allows certain molecules to pass across into the bloodstream such as vitamins, minerals and digested foods. It also acts as a barrier to prevent entry of larger damaging molecules, foreign particles and bacteria.

When there is damage to the intestinal lining it can open up slightly and this allows larger particles, such as undigested or partially digested foods and bacteria, to enter into the bloodstream. This leads to malabsorption of nutrients as they pass through into the bloodstream in a form that the body cannot use, and can also lead to excessive absorption of bacteria and other molecules that the intestines usually prevent from entering the blood stream.

The immune system is not used to these particles and sees them as foreign, causing food sensitivities and candida infections. This can lead to inflammation, irritation and allergic like reactions. Both malabsorption and increased intestinal permeability (“leaky gut”) are associated with chronic gastrointestinal imbalances as well as many systemic disorders.

The Cyrex Array 2 Intestinal Antigenic Permeability Screen™ identifies an immune response indicating damage to the intestinal mucosal microstructures, including the epithelial cell network and the intercellular tight junctions. Measuring the continuity of the intestinal barrier is accomplished by identifying antibodies against the tight junction proteins (occludin and zonulin) and antibodies to the actomyosin network (a protein complex that regulates intestinal barrier function by maintaining the plasticity of tight junctions).

This test tests for IgG, IgA and IgM antibodies.

At Smart Nutrition we pride ourselves in offering the best cost possible for the Cyrex Array 2 Intestinal Antigenic Permeability Screen test.

  • Inflammatory bowel disease (IBD)
  • Food allergy
  • Inflammatory joint disease
  • Chronic skin conditions such as psoriasis and eczema
  • Rheumatoid arthritis
  • Vasculitis
  • Ankylosing spondylitis


Possible causes of intestinal permeability include:

  • Intestinal infection
  • Ingestion of foods or toxic chemicals
  • Deficiency of secretory IgA
  • Trauma and endotoxemia
  • NSAIDs
Decreased permeability is a fundamental cause of malabsorption and subsequent malnutrition: failure to thrive. In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase while permeability to small molecules decreases, a result of damage to the microvilli – finger-like projections that line the gut wall. As a result the correct nutrients levels become even less available to the body and it becomes less able to assist in the detoxification of antigens flooding the system.


The the cyrex array 2 intestinal antigenic permeability screen test measures:

  • Actomyosin IgA
  • Occludin/Zonulin IgG
  • Occludin/Zonulin IgA
  • Occludin/Zonulin IgM
  • Lipopolysaccharides (LPS) IgG
  • Lipopolysaccharides (LPS) IgA
  • Lipopolysaccharides (LPS) IgM

The cyrex array 2 intestinal antigenic permeability screen test is a blood test that requires a blood sample which will then need to be centrifuged. Centrifuge can be carried out at the lab if the sample is received within 24 hours from the blood draw.

You will need to arrange for a blood sample to be collected either at a laboratory in London, by a nurse at your GP service or at a private clinic or hospital. Any fee for this service is not included with the test fee.

While Cyrex is unable to provide an exhaustive list of medications due to the interactive complexities and varieties of medications and patient circumstances, the following has been noted:

  • Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false negative results.
  • Limited assessments on the effects of aspirin, acetaminophen, and antipsychotics on Arrays 1-4 have been performed. No noticeable effects were observed.
  • Inhalers can affect the results of Cyrex’s oral fluid testing (Array 1). Wait two weeks after completion of inhalant dosages before collecting the specimen.
  • Unknown cross-reactive epitopes from foods and microorganisms may stimulate the antibody production in the absence of a true antigen. Cyrex has already developed Array 4 in order to recognise the most common antigens in this regard.
  • A gluten-free diet can cause false negative results on gluten protein/peptide tests.
  • Certain conditions, such as ileal pouch surgery, may cause a false positive celiac serology.

Please do not stop any medication without your doctor’s consent.


Once you’ve collected your sample for the cyrex array 2 intestinal antigenic permeability screen test, you’ll need to send it back to the lab via a next day service, which is offered by Royal Mail if you’re in the UK. If you’re outside of the UK, please check with your postal service for options. The cost of the test does not cover the return postage.

Please note that samples should only be posted on Monday – Thursday so that they do not arrive over the weekend when the lab is closed.

3 years and above.

21 days.

Your test results will be emailed to you.


Cyrex Array 2 Leaky Gut

related tests

Cyrex Array 10 Multiple Food Reactivity Screen 180 foods test


Cyrex Array 12 Pathogen Immune


Cyrex Array 20 Blood Brain Barrier / Leaky Brain


Cyrex Array 4 Gluten Associated Food Reactivity Screen 29 foods


Cyrex Array 3 Wheat and Gluten Reactivity Screen


Cyrex Array 5 Multiple Autoimmune Screen



Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.