Test your Nutrient Requirement Genes and support any areas that are compromised.
Test your Histamine Intolerance Genes and support any areas that are compromised.
Test your Histamine Intolerance Genes and support any areas that are compromised.
Histamine acts as a signalling chemical that is released from your immune system to communicate with your cells. It is most known for its role in the digestive system and causing allergic symptoms in response to foods or environmental triggers (pollen and mould are common environmental triggers). In this instance, histamine will be released by the white blood cells in response to the body’s perceived allergen. Histamine is stored mainly in mast cells but also found in basophils in the blood.
Histamine has other important roles in the body including regulating your sleep cycle, protecting against infection, cognitive function and communicating messages to the brain and nervous system, thus acting as a neurotransmitter.
Once created, histamine needs to be stored or broken down by the enzyme, diamine oxidase (DAO) in the gut and histamine-n-methyltransferase (HNMT) in the lungs and nervous system. The process of histamine degradation can be affected by genetic and environmental factors. In some cases can lead to histamine toxicity, with symptoms presenting similar to an allergic reaction.
Histamine intolerance develops when there is an imbalance between histamine released and the body’s ability to break this down. Accumulated histamine in the body, quickly becomes toxic and leads to symptoms similar to allergic reactions.
The genetic histamine intolerance test looks at the genes, nutrients, lifestyle and environmental factors that are involved in both the breakdown and removal of histamine. Focusing on where breakdowns in the cycle occur means that optimal function can be supported. It also looks at important cofactors of this cycle, such as vitamin B6.
Primarily when histamine intolerance is present, there is a breakdown in the DAO pathway, due to gastrointestinal issues or because of the intake of DAO inhibitors. For some, it will be genetic predisposition that exposes them to histamine intolerance.
HNMT controls the neurotransmitters activity of histamine in the brain and regulates the airways response, so important in conditions like asthma.
Understanding the genetic triggers of histamine intolerance means that some of the common triggers can be identified and a plan put in place for these, including:
If your histamine pathways are not working correctly then it can increase susceptibility to various health conditions. Symptoms can include:
Skin disorders – eczema, hives, itchiness and redness
Digestive – acid reflux, diarrhoea, nausea and vomiting
Respiratory – runny nose, nasal congestion, asthma, chronic cough or throat clearing, breathing difficulties
Neurological – anxiety, headaches, insomnia, memory and concentration problems and ADHD
Vascular – low blood pressure, fainting, dizziness, rapid heartbeat, headaches/migraines, oedema
The genetic histamine intolerance test assesses genes associated with the sub-cycles below:
Nervous System and Immune: HNMT, MAOB and NAT2
Methylation: MTHFR
Gastro Intestinal: ALDH2, DAO and GPX1
We have a team of functional medicine practitioners and registered nutritional therapists that we can refer you to help you with your results should you need any additional support. This is not included in the cost of the test.
Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.
The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.
At Smart Nutrition we pride ourselves in offering the best cost possible for the Genetic Histamine Intolerance test.
If your histamine pathways are not working correctly then it can increase susceptibility to various health conditions. Symptoms can include:
Skin disorders – eczema, hives, itchiness and redness
Digestive – acid reflux, diarrhoea, nausea and vomiting
Respiratory – runny nose, nasal congestion, asthma, chronic cough or throat clearing, breathing difficulties
Neurological – anxiety, headaches, insomnia, memory and concentration problems and ADHD
Vascular – low blood pressure, fainting, dizziness, rapid heartbeat, headaches/migraines, oedema
The genetic histamine intolerance test assesses genes associated with the sub-cycles below:
Nervous and Immune: HNMT, MAOB and NAT2
Methylation: MTHFR
Gastro Intestinal: ALDH2, DAO and GPX1
Buccal cheek swab.
Collecting your samples for the genetic histamine intolerance test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.
You need to have a break from eating and drinking at least one hour before doing the genetic histamine intolerance test.
As the test is looking at genetic code, which is fixed, the test is not impacted by illness, infections, medication, the food you eat, or supplements you take. To avoid contamination of the sample, please abstain from eating/drinking for at least 1 hour before testing.
The genetic histamine intolerance test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.
Results for the genetic histamine intolerance test are available in 2.5 weeks.
Your genetic histamine intolerance test results will be emailed to you.
We are here to offer ongoing support as you progress through your health journey, regardless of your test results. Should you have any inquiries or require additional assistance we are happy to help you.
If you feel you need additional support in addressing your health concerns, we suggest considering collaboration with the Functional Medicine and Nutrition Consultations Clinic. (website coming soon)
Karen Preece Smith
Genetics and Nutrition Function Medicine:
As you can see Olga and Karen can help you address areas highlighted by your genetic histamine intolerance test results, crafting a personalised plan tailored to your specific needs. This comprehensive approach would include recommendations regarding your genetic histamine intolerance test results and any necessary further diagnostic testing depending on your goals, supplementation, dietary adjustments, and lifestyle recommendations, all presented with clear, easy-to-follow guidance.
How to Book your appointment
£150 an hour but you will also receive a £20 off your first appointment discount code with the results.
Many people book a 1 hour session to go over and understand their results.And lots of people want further ongoing support as they want to address their health concerns in more details.
We use lifecodeGX for our genetic histamine intolerance test.
Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction after 5 months and completely destroyed by 6 months.
Please see the ISO Certifications below:
LifeCodeGx does not provide the raw data. It is only used as a means to produce the report and therefore not produced in the report.
If you did your genetic test within 3 months we can upgrade it without you needing a new DNA kit.
We don’t use data from any third parties like 23&Me. Unfortunately, it doesn’t include many of the important SNPs that are needed to perform our analysis and produce our detailed reports. We also prefer to use our own testing and data for confidentiality reasons. All of our packages include a Lifecode Gx DNA test to ensure completeness and accuracy.
All sample reports are for representational and educational purposes only. Biomarkers, references ranges, results, and all other data may differ from actual reports. All data included in no way represents an actual patient. Any comparisons of results to actual patients is completely incidental.Â
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Test your Nutrient Requirement Genes and support any areas that are compromised.
£243.00
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Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.
The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.