Genetic Methylation Test

Genetic Methylation Test

Gary Brecka tells Steven Bartlett that Methylation Matters.

Methylation, has been discussed on Steven Bartlett’s DOAC  – Diary of a CEO Podcast with his guest Gary Brecka – If you would like a listen head here to the  ‘World No. 1 Biohacking expert” episode on the Steven Bartlett DOAC  – Diary of a CEO Podcast.

Gary Brecka also discusses The Genetic Methylation Test on The Health Optimisation Podcast with Tim Grey. Head here to have a listen;  “Detox or die – Why modern life demands a new health strategy with Gary Brecka

Gary will also be speaking at the June 2024 Health optimisation summit in London.

We cover everything in the Gary Brecka 10X DNA test mentioned on the podcast and 22 extra genes meaning we offer the most comprehensive Genetic methylation test in the UK.

What is Methylation?

Occurring billions of times per second in every cell, is a fundamental chemical process. For enthusiasts of chemistry, it involves the addition of a methyl group. This simple addition of a methyl group acts as a trigger, activating countless switches that regulate, switch on and off many processes within the body.

As well as acting as billions of these switches methyl groups, help regulate mood, detoxify hormones, produce energy and promote healthy ageing.

The process of methylation requires vitamins, minerals and amino acids from the diet to keep this process running smoothly. Genetic factors and oxidative stressors can also affect how well this pathway works.

GET £20 off your 2nd, 3rd, 4th etc test results. A simple and cost effective way to get the whole family checked out!

Why is Methylation Important?

Methylation is involved in basic energy production, fat metabolism, immune responses, vascular health and cell membrane repair. It is needed to create DNA and RNA and regulate gene expression. Methylation helps make creatine, required for skeletal muscle contraction, and it produces and metabolises neurotransmitters to regulate mood. It also works to neutralise toxins and hormones.

Methylation has an all-encompassing role in basic human physiology, so the range of symptoms associated with methylation defects is broad.

What does the Genetic Methylation Test do?

The Genetic Methylation Test looks at your DNA to find tiny differences called SNPs, which can affect your health and how your body works. These differences can influence things like how your body processes nutrients and medications. Understanding them helps you make better choices for your health

The Genetic Methylation Test reveals whether an individual might struggle with or excel in processing cofactors like B6, B9 (folate), B12 (cobalamin), methionine, betaine, choline, zinc, and magnesium. Additionally, it identifies potential inhibitors such as chemicals, molds, drugs, hormones, and heavy metals. This information guides strategies to address or work around any bottlenecks or weaknesses in the methylation pathway.

Who would benefit most from the Genetic Methylation Test?

An imbalance in methylation, whether it’s too little or too much, can increase susceptibility to various chronic health conditions. These include;

  • Poor detoxification  (including those undergoing hormone therapy, alcohol consumption, or toxin exposure)
  • Cardiovascular issues (such as non-coronary atherosclerosis, hypertension, or coronary artery disease, circulatory issues)
  • Psychiatric and mood disorders (including schizophrenia, autism, bipolar disorder, anxiety, and depression)
  • Neurological disorders (such as Parkinson’s disease and cognitive decline)
  • Immune and autoimmune disorders
  • Sensitivities to food and chemicals
  • Chronic fatigue
  • Infertility
  • Premature ageing

How does our genetic Methylation Test differ form Gary Brecka 10X methylation test?

The Gary Brecka methylation test isn’t available in the UK but our genetic methylation test covers all the genes in the Gary Brecka methylation test.

The genetic testing offered by Gary Brecka checks for five specific gene mutations, namely:

  1. COMT
  2. AHCY
  3. MTRR
  4. MTR
  5. MTHFR

Our genetic methylation test covers everything in the Gary Brecka test (in bold below) and an additional 22 genes.

Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD

What will I get with the genetic methylation test results?

  1. Clearly illustrated and customized, color-coded genotype information .
  2. Descriptions elaborating on your gene functionality and the effects of SNP (Single Nucleotide Polymorphism).
  3. Clinically significant SNPs.
  4. Insights into nutrient and other epigenetic influences.
  5. A fully referenced report with links to research evidence.

What if I need help with the results of the genetic methylation test results?

We have a team of functional medicine practitioners and registered nutritional therapists that we can refer you to to help you with your results should you need any additional support. This is not included in the cost of the test.

What happens to my DNA after the Genetic Methylation test?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.

The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.

At Smart Nutrition we pride ourselves in offering the best cost possible for the Genetic Methylation test.

 

 

GET £20 off your 2nd, 3rd, 4th etc test results. A simple and cost effective way to get the whole family checked out!
Discount applied at checkout.

Defects in methylation are wide and varied and have been associated with many clinical conditions including, but not limited to:

Autism
ADHD
Cardiovascular disease
Congenital and neural tube defects
Cognitive decline
Chronic fatigue
Depression
Cardiovascular disease
Parkinson’s
Schizophrenia

The genetic Methylation Test assesses genes associated with five sub-cycles:

Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD

Buccal cheek swab.

Collecting your samples for the genetic methylation test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.

You need to have a break from eating and drinking at least one hour before doing the genetic methylation test.

The genetic methylation test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.

 

UK Orders

All UK orders for the genetic methylation test include return packaging and postage for return within the UK. The package can be put in a standard post box.
It can also be sent tracked or special delivery via a post office, the fee for this is not included.

Non UK Orders

The DNA test kit is declared as a value of £4 for customs purposes. The package may be subject to customs/ import duties, for which the recipient is liable and responsible to settle.
If kits are returned due to you not accepting fees or delivery, we are sorry but the order is not refundable.International orders return packaging is provided but it is NOT prepaid. You will need to arrange and pay for the return. For returns from Europe we recommend a tracked postal service. As samples are stable it is not necessary to choose an express service.
For Non UK orders please contact [email protected] if your country is not available at the checkout.

 

 

Results for the genetic methylation test are available in 2.5 weeks.

Your genetic methylation test results will be emailed to you.

We are here to offer ongoing support as you progress through your health journey, regardless of your test results. Should you have any inquiries or require additional assistance we are happy to help you.

Your next steps

If you feel you need additional support in addressing your health concerns, we suggest considering collaboration with the Functional Medicine and Nutrition Consultations Clinic. (website coming soon)

Renowned for their expertise, the Functional Medicine and Nutrition Consultations Clinic comprises a team of experienced nutritional therapists and certified functional medicine practitioners who excel in addressing complex health issues.Working with genetic test results needs specialised training. Chosen carefully both Olga Hamilton and Karen Preece Smith have completed their nutrigenomics training and are ready to help you.

More information about the team of qualified functional medicine and registered Nutritional therapy practitioners that are ready to help you.

Karen Preece Smith 

Methylation and Nutrition Function Medicine:
Karen has worked with nutrigenomics since 2019. She has undertaken further training with leading UK genetic lab, Lifecode Gx, to become one of their recognised Nutrigenomic practitioners. She understands Methylation genes well and can simplify their findings in relation to your CFS, digestive or hormonal issues as well as those issues which affect mental health and neurodiversity.
Olga Hamilton
Olga has been using DNA/genetics testing in her practice since 2015 to help her build personalised wellbeing and anti-ageing programmes. Genetic testing tells us how and where you are different from all other people, not just disease risks and predispositions, but also helps us tailor your diet and micronutrients. It is extremely helpful in personalising your diet and helps in prevention of genetic disorders.

As you can see Olga and Karen can help you address areas highlighted by your genetic methylation test results, crafting a personalised plan tailored to your specific needs. This comprehensive approach would include recommendations regarding your Genetic methylation test results and any necessary further diagnostic testing depending on your goals, supplementation, dietary adjustments, and lifestyle recommendations, all presented with clear, easy-to-follow guidance.How to Book your appointment

We will send you details of how to book with the clinic along with your results.

How much will it cost.

£150 an hour but you will also receive a £20 off your first appointment discount code with the results.

How many sessions will I need to understand my genetic methylation test result

Many people book a 1 hour session to go over and understand their results.And lots of people want further ongoing support as they want to address their health concerns in more details.

Which lab do you use to process the genetic methylation test results?

We use lifecodeGX for our genetic methylations test.

 

Is the laboratory processing my genetic methylation results accredited and reputable?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction after 5 months and completely destroyed by 6 months.

Please see the ISO Certifications below:

  • Certification to ISO 9001 for business processes;
  • Certification to ISO 13485 for the manufacturing of substances that support health care processes and systems;
  • Accreditation to ISO 17025, for laboratory testing and calibration services;
  • Compliance with Good Laboratory Practice (GLP), Good Clinical Practice (GCP), Good Distribution Practice (GDP) and current Good Manufacturing Practice (cGMP) for pharmaceutical studies and pharmaceutical related processes;
  • Accreditation to ISO 17043 for the operation and management of proficiency testing schemes;
  • Accreditation to ISO 17034 for reference material production facilities.

Genetic Methylation Test

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PUT YOURSELF to the TEST

Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.