Genetic Methylation Test

Genetic Methylation Test

What is Methylation?

Methylation is a chemical process that happens billions of times per second in every cell of the body and acts like billions of switches within the body – turning processes on and off, influencing and changing many things. Methyl groups that relate to methylation also help regulate mood, detoxify hormones, produce energy and promote healthy ageing.

The process of methylation requires vitamins, minerals and amino acids from the diet to keep this process running smoothly. Genetic factors and oxidative stressors can also affect how well this pathway works.

Why is Methylation Important?

Methylation is involved in basic energy production, fat metabolism, immune responses, vascular health and cell membrane repair. It is needed to create DNA and RNA and regulate gene expression. Methylation helps make creatine, required for skeletal muscle contraction, and it produces and metabolises neurotransmitters to regulate mood. It also works to neutralise toxins and hormones.

Methylation has an all-encompassing role in basic human physiology, so the range of symptoms associated with methylation defects is broad.

What does the Genetic Methylation Test do?

The Genetic Methylation Test looks at your DNA to find tiny differences called SNPs, which can affect your health and how your body works. These differences can influence things like how your body processes nutrients and medications. Understanding them helps you make better choices for your health

The Genetic Methylation Test reveals whether an individual might struggle with or excel in processing cofactors like B6, B9 (folate), B12 (cobalamin), methionine, betaine, choline, zinc, and magnesium. Additionally, it identifies potential inhibitors such as chemicals, molds, drugs, hormones, and heavy metals. This information guides strategies to address or work around any bottlenecks or weaknesses in the methylation pathway.

Who would benefit most from the Genetic Methylation Test?

An imbalance in methylation, whether it’s too little or too much, can increase susceptibility to various chronic health conditions. These include;

  • Poor detoxification  (including those undergoing hormone therapy, alcohol consumption, or toxin exposure)
  • Cardiovascular issues (such as non-coronary atherosclerosis, hypertension, or coronary artery disease, circulatory issues)
  • Psychiatric and mood disorders (including schizophrenia, autism, bipolar disorder, anxiety, and depression)
  • Neurological disorders (such as Parkinson’s disease and cognitive decline)
  • Immune and autoimmune disorders
  • Sensitivities to food and chemicals
  • Chronic fatigue
  • Infertility
  • Premature aging

How does our genetic Methylation Test differ form Gary Brecka 10X methylation test?

The Gary Brecka methylation test isn’t available in the UK but our genetic methylation test covers all the genes in the Gary Brecka methylation test.

The genetic testing offered by Gary Brecka checks for five specific gene mutations, namely:

  1. COMT
  2. AHCY
  3. MTRR
  4. MTR
  5. MTHFR

Our genetic methylation test covers everything in the Gary Brecka test (in bold below) and an additional 22 genes.

Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD

What will I get with the genetic methylation test results?

  1. Clearly illustrated and customized, color-coded genotype information .
  2. Descriptions elaborating on your gene functionality and the effects of SNP (Single Nucleotide Polymorphism).
  3. Clinically significant SNPs.
  4. Insights into nutrient and other epigenetic influences.
  5. A fully referenced report with links to research evidence.

What if I need help with the results of the genetic methylation test results?

We have a team of functional medicine practitioners and registered nutritional therapists ready to help you with your results should you need any further support.

What happens to my DNA after the Genetic Methylation test?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.

The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.


Defects in methylation are wide and varied and have been associated with many clinical conditions including, but not limited to:

Cardiovascular disease
Congenital and neural tube defects
Cognitive decline
Chronic fatigue
Cardiovascular disease

The genetic Methylation Test assesses genes associated with five sub-cycles:

Folate Cycle: DHFR, FOLH1, MTHFD1, MTHFR, RFC1, SHMT1 and TYMS
Methionine Cycle: AHCY, BHMT, CHDH, FUT2, MAT1A, MTR, MTRR, PEMT and TCN2
Neurotransmitter Cycle: COMT, MAOA, MAOB, MTHFR, PNMT, QDPR and VDR
Transsulphuration Cycle: CBS, CTH, GSS, MUT and SUOX
Urea Cycle: BDKRB2, NOS and SOD

Buccal cheek swab.

Collecting your samples for the genetic methylation test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.

You need to have a break from eating and drinking at least one hour before doing the genetic methylation test.

The genetic methylation test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.


All UK orders for the genetic methylation test include return packaging and postage for return within the UK. The package can be put in a standard post box.
It can also be sent tracked or special delivery via a post office, the fee for this is not included.





Results for the genetic methylation test are available in 2 weeks.

Your genetic methylation test results will be emailed to you.

Genetic Methylation Test


Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.