Metabolomix+ Previously ONE

Metabolomix+ Previously ONE

The Metabolomix+, previously the ONE test, highlights individual nutritional recommendations for protective antioxidants, B-vitamins, minerals and amino acids.

This unique profile only requires one urine sample first thing in the morning, making it a great screening tool that is easy to do at home!

The laboratory assess levels of organic acids in the urine sample. These can highlight reduced or blocked metabolic function. This can be due to a nutrient deficiency, a lack of an enzyme needed to metabolise correctly, toxic build-up such as heavy metals or the effect of a drug or medication.

Enzymes that are responsible for metabolising organic acids need vitamins and minerals to work. Therefore raised levels of organic acids can reflect a functional need for these nutrients despite normal serum levels. These research studies go into detail about this: Ref 1,  Ref 2, Ref 3, Ref 4, Ref 5.


The Metabolmix+ can be used to evaluate your overall nutritional status and assess the functional need for vitamins and minerals and antioxidants. This can be helpful when evaluating the cause of many conditions including:

  • Mood disorders
  • Mitochondrial dysfunction
  • Fatigue
  • Chronic stress
  • Inflammation

Results come with a concise and and easy interpretation showing clear, personalised recommendations for supplementation of:

  • Antioxidants
  • B-vitamins
  • Minerals
  • Digestive support
  • Amino acids


The Metabolomix+ test evaluates the following:

Organic acids (urine)
Malabsorption and dysbiosis markers are metabolites produced by the gastrointestinal microbiome.
Cellular energy and mitochondrial markers are biomarkers of carbohydrate and fatty acid metabolism, and the citric acid (Kreb’s) cycle.
Vitamin markers are specific analytes used to assess functional levels of vitamin cofactors.
Neurotransmitter metabolites are downstream byproducts of epinephrine, norepinephrine, serotonin and dopamine.
Toxin and detoxification markers relate to certain toxic metabolites and the body’s detoxification capacity.
Oxalate markers relate to kidney stone formation, oxidative stress and metabolic dysfunction.

Amino acids (urine)
Essential amino acids must be derived from dietary sources.
Nonessential amino acids are synthesised by the body.
Intermediary metabolites are byproducts of amino acid metabolism.
Dietary peptide related markers can indicate incomplete protein breakdown.

Oxidative stress markers (urine)
Include the oxidative damage markers lipid peroxides and 8-OH.


Add-on essential and metabolic fatty acids (bloodspot)

Omega 3 fatty acids are essential for brain function and cardiovascular health and are anti-inflammatory.
Omega 6 fatty acids are involved in the balance of inflammation.
Omega 9 fatty acids are important for brain growth, nerve cell myelin, and reducing inflammation.
Saturated fatty acids are involved in lipoprotein metabolism and adipose tissue inflammation.
Monounsaturated fats include omega 7 fats and unhealthy trans fats.
Delta-6 desaturase activity assesses efficiency of this enzyme to metabolise omega 6s and omega 3s.
Cardiovascular risk includes specific ratios and the omega 3 index.

Add-on Nutrient and Toxic Elements (urine)

Assesses 20 toxic and 15 mineral elements.

Add-on SNPs – buccal swab



Urine sample.
If the genetic add ons are requested, a buccal swab is also required.
If the essential fatty acids are requested, a finger prick blood test is also required.

2 days before you collect your samples
Discontinue all of the following unless you are monitoring your supplements and diet with your practitioner:

Supplements containing creatine, vitamin C or any other mineral elements that are being analysed by this test.
Any other substances that may influence urinary element excretion of elements.

You must continue with the above food and supplement restrictions until all your samples are collected.

Consult your GP or practitioner before stopping and prescribed medication.

The day before your test
Eat your usual diet, but do not over-consume any single food or adhere to an extreme diet.
Fluid intake should be limited to 2 litres of fluid over the preceding 24 hour period.



2 years and above.

Please return via a next day service Monday – Thursday only. A courier option is sent with your test kit. You pay the laboratory directly for this test and also the return courier if you use the service. You can also make your own arrangements for returning your samples via a next day service.

21 working days.

Your test results will be emailed to you.

Metabolomix+ Previously ONE