Test your Nutrient Requirement Genes and support any areas that are compromised.
Test your Detoxification Genes and support any areas that are compromised.
Test your Detoxification Genes and support any areas that are compromised.
The human body is exposed to thousands of toxins daily that need to be detoxified. Substances such as environmental pollutants, food additives, pesticides, medications, alcohol, and hormones need to be processed so that they can be excreted via urine and bile. This detoxification process is primarily performed by the liver but it also involves the small intestine, kidneys, and lungs to a lesser extent.
This process transforms substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol, and hormones from fat-soluble to water-soluble forms, making them easier to excrete.
Detoxification occurs in two main phases, with a lesser known third phase, that are detailed below:
Phase I, also known as Reactions, prepares toxic molecules for deactivation
Phase II, known as Conjugation, finishes this deactivation process and prepares for elimination
Phase III, which focuses on Antiporter Activity.
Given the importance of detoxification in the body if this isn’t working correctly, then it can lead to a range of symptoms, including hormonal, digestive and immune, that are detailed further below.
These pathways can be influenced by genetic variances but also other factors including nutrition, sex, age and lifestyle factors such as smoking and caffeine consumption.
Toxins can be exogenous or endogenous and both can be harmful to the body. Examples of exogenous toxins are alcohol, smoking, environmental pollutants) pesticides and herbicides), diet (trans-fats, excess sugar and food additives), mould, pharmaceutical drugs, heavy metals, cosmetics, water and many more.
Endogenous toxins are created within the body and can be by-products of these processes such as digestion, stress, dysbiosis, infections, histamine and other inflammatory reactions.
When we are assessing the livers function the toxic load of an individual is important and how easily the liver can process these. A high toxic load can be due to the body’s ability to process these or a really high exposure to toxins that overloads the body.
The Genetic Detoxification Test looks at your DNA to find tiny differences called SNPs, which can affect your body’s ability to detoxify. The specific genes that this test looks at are related to the 3 phases of liver detoxification discussed above:
Phase I – focusing on reactions in the liver, including the cytochrome P450 oxidases. As part of this phase it also looks at genes that help neutralise Reactive Oxygen Species (ROS), generated in this phase.
Phase II – conjugation, including the UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs),
Phase III – antiporter gene, ABCB1, which affects the transport of medicines and other substances into and out of cells.
This information is then used to provide 5 personalised summary pathways that include:
This information guides strategies to address or work around any weaknesses or insufficiencies in the detoxification pathway.
If your detoxification pathways are not working correctly then it can increase susceptibility to various health conditions. These include:
Hormonal – including PMS, weight gain, anxiety, depression, mood swings, low libido and infertility
Immune – recurrent and frequent infections, asthma, food allergies and skin rashes and itchiness
Digestive – constipation, diarrhoea, bloating, fatty stools, halitosis (bad breath), bitter taste, intolerance to fatty foods, acid reflux and heartburn
Neurological – headaches, poor memory and concentration, dementia or neuralgia and low stress tolerance
Muscular – muscle aches and pains, arthritis
Increased sensitivity to chemicals and odours is a strong indication, in addition to chronic fatigue and premature ageing.
The genetic detoxification test assesses genes associated with the sub-cycles below:
CYP450s: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4
Alcohol: ADH1B, ADH1C and ALDH2
Pesticides: PON1
ROS: SOD2, GPX1 and NQO1
Glucuronidation: UGT1A1, UGT1A6
Methylation: COMT and TPMT
Sulphonation: SULT1A1, SULT1E1 and SULT2A1
Acetylation: NAT1 and NAT2
Glutathione: GSTM1, GSTP1 and GSTT1
Antiporter: ABCB1
We have a team of functional medicine practitioners and registered nutritional therapists that we can refer you to help you with your results should you need any additional support. This is not included in the cost of the test.
Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.
The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.
At Smart Nutrition we pride ourselves in offering the best cost possible for the Genetic Detoxification test.
Defects in detoxification are wide and varied and have been associated with many clinical conditions including, but not limited to:
Obesity
Asthma
Cardiovascular disease
Diabetes
Neurodegenerative conditions including Alzheimer’s Disease
The genetic detoxification test assesses genes associated with the sub-cycles below:
CYP450s: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4
Alcohol: ADH1B, ADH1C and ALDH2
Pesticides: PON1
ROS: SOD2, GPX1 and NQO1
Glucuronidation: UGT1A1, UGT1A6
Methylation: COMT and TPMT
Sulphonation: SULT1A1, SULT1E1 and SULT2A1
Acetylation: NAT1 and NAT2
Glutathione: GSTM1, GSTP1 and GSTT1
Antiporter: ABCB1
Buccal cheek swab.
Collecting your samples for the genetic detoxification test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.
You need to have a break from eating and drinking at least one hour before doing the genetic detoxification test.
As the test is looking at genetic code, which is fixed, the test is not impacted by illness, infections, medication, the food you eat, or supplements you take. To avoid contamination of the sample, please abstain from eating/drinking for at least 1 hour before testing.
The genetic detoxification test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.
Results for the genetic detoxification test are available in 2.5 weeks.
Your genetic detoxification test results will be emailed to you.
We are here to offer ongoing support as you progress through your health journey, regardless of your test results. Should you have any inquiries or require additional assistance we are happy to help you.
If you feel you need additional support in addressing your health concerns, we suggest considering collaboration with the Functional Medicine and Nutrition Consultations Clinic. (website coming soon)
Karen Preece Smith
Genetics and Nutrition Function Medicine:
As you can see Olga and Karen can help you address areas highlighted by your genetic detoxification test results, crafting a personalised plan tailored to your specific needs. This comprehensive approach would include recommendations regarding your Genetic detoxification test results and any necessary further diagnostic testing depending on your goals, supplementation, dietary adjustments, and lifestyle recommendations, all presented with clear, easy-to-follow guidance.
How to Book your appointment
£150 an hour but you will also receive a £20 off your first appointment discount code with the results.
Many people book a 1 hour session to go over and understand their results.And lots of people want further ongoing support as they want to address their health concerns in more details.
We use lifecodeGX for our genetic detoxification test.
Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction after 5 months and completely destroyed by 6 months.
Please see the ISO Certifications below:
LifeCodeGX does not provide the raw data. It is only used as a means to produce the report and therefore not produced in the report.
If you did your genetic test within 3 months we can upgrade it without you needing a new DNA kit.
We don’t use data from any third parties like 23&Me. Unfortunately, it doesn’t include many of the important SNPs that are needed to perform our analysis and produce our detailed reports. We also prefer to use our own testing and data for confidentiality reasons. All of our packages include a Lifecode Gx DNA test to ensure completeness and accuracy.
All sample reports are for representational and educational purposes only. Biomarkers, references ranges, results, and all other data may differ from actual reports. All data included in no way represents an actual patient. Any comparisons of results to actual patients is completely incidental.
Updated
Test your Nutrient Requirement Genes and support any areas that are compromised.
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Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.
The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.