Genetic Detoxification Test

Test your Detoxification Genes and support any areas that are compromised.

Genetic Detoxification Test

Test your Detoxification Genes and support any areas that are compromised.

What is Detoxification?

The human body is exposed to thousands of toxins daily that need to be detoxified. Substances such as environmental pollutants, food additives, pesticides, medications, alcohol, and hormones need to be processed so that they can be excreted via urine and bile. This detoxification process is primarily performed by the liver but it also involves the small intestine, kidneys, and lungs to a lesser extent.

This process transforms substances such as nutrients, food additives, pesticides, medications, air pollutants, alcohol, and hormones from fat-soluble to water-soluble forms, making them easier to excrete.

Detoxification occurs in two main phases, with a lesser known third phase, that are detailed below:

Phase I, also known as Reactions, prepares toxic molecules for deactivation

Phase II, known as Conjugation, finishes this deactivation process and prepares for elimination

Phase III, which focuses on Antiporter Activity.

Given the importance of detoxification in the body if this isn’t working correctly, then it can lead to a range of symptoms, including hormonal, digestive and immune, that are detailed further below. 

These pathways can be influenced by genetic variances but also other factors including nutrition, sex, age and lifestyle factors such as smoking and caffeine consumption.

Why is Detoxification Important?

Toxins can be exogenous or endogenous and both can be harmful to the body. Examples of exogenous toxins are alcohol, smoking, environmental pollutants) pesticides and herbicides), diet (trans-fats, excess sugar and food additives), mould, pharmaceutical dugs, heavy metals, cosmetics, water and many more.

Endogenous toxins are created within the body and can be by-products of these processes such as digestion, stress, dysbiosis, infections, histamine and other inflammatory reactions.

When we are assessing the livers function the toxic load of an individual is important and how easily the liver can process these. A high toxic load can be due to the body’s ability to process these or a really high exposure to toxins that overloads the body.

What does the Genetic Detoxification Test do?

The Genetic Detoxification Test looks at your DNA to find tiny differences called SNPs, which can affect your body’s ability to detoxify. The specific genes that this test looks at are related to the 3 phases of liver detoxification discussed above:

Phase I – focusing on reactions in the liver, including the cytochrome P450 oxidases. As part of this phase it also looks at genes that help neutralise Reactive Oxygen Species (ROS), generated in this phase.

Phase II – conjugation, including the UDP-glucuronosyltransferases (UGTs) and glutathione S-transferases (GSTs),

Phase III – antiporter gene, ABCB1, which affects the transport of medicines and other substances into and out of cells.

This information is then used to provide 5 personalised summary pathways that include:

  • Alcohol
  • Mould
  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Paracetamol
  • Polycyclic aromatic hydrocarbons (PAHs)

 

This information guides strategies to address or work around any weaknesses or insufficiencies in the detoxification pathway.

 

Who would benefit most from the Genetic Detoxification Test?

If your detoxification pathways are not working correctly then it can increase susceptibility to various health conditions. These include:

Hormonal – including PMS, weight gain, anxiety, depression, mood swings, low libido and infertility

Immune – recurrent and frequent infections, asthma, food allergies and skin rashes and itchiness

Digestive – constipation, diarrhoea, bloating, fatty stools, halitosis (bad breath), bitter taste, intolerance to fatty foods, acid reflux and heartburn

Neurological – headaches, poor memory and concentration, dementia or neuralgia and low stress tolerance

Muscular – muscle aches and pains, arthritis

Increased sensitivity to chemicals and odours is a strong indication, in addition to chronic fatigue and premature ageing.

 

What is being measured in the Genetic Detoxification Test 

The genetic detoxification test assesses genes associated with the sub-cycles below:

CYP450s: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4
Alcohol: ADH1B, ADH1C and ALDH2
Pesticides: PON1
ROS: SOD2, GPX1 and NQO1
Glucuronidation: UGT1A1, UGT1A6
Methylation: COMT and TPMT
Sulphonation: SULT1A1, SULT1E1 and SULT2A1
Acetylation: NAT1 and NAT2
Glutathione: GSTM1, GSTP1 and GSTT1
Antiporter: ABCB1

What will I get with the genetic detoxification test results?

  1. Clearly illustrated and customized, color-coded genotype information .
  2. Descriptions elaborating on your gene functionality and the effects of SNP (Single Nucleotide Polymorphism).
  3. Clinically significant SNPs.
  4. Insights into nutrient and other epigenetic influences.
  5. A fully referenced report with links to research evidence.

What if I need help with the results of the genetic detoxification test results?

We have a team of functional medicine practitioners and registered nutritional therapists that we can refer you to help you with your results should you need any additional support. This is not included in the cost of the test.

What happens to my DNA after the Genetic Detoxification test?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.

The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.

At Smart Nutrition we pride ourselves in offering the best cost possible for the Genetic Detoxification test.

 

Defects in detoxification are wide and varied and have been associated with many clinical conditions including, but not limited to:

Obesity

Asthma

Cardiovascular disease

Diabetes

Neurodegenerative conditions including Alzheimer’s Disease

 

The genetic detoxification test assesses genes associated with the sub-cycles below:

CYP450s: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4
Alcohol: ADH1B, ADH1C and ALDH2
Pesticides: PON1
ROS: SOD2, GPX1 and NQO1
Glucuronidation: UGT1A1, UGT1A6
Methylation: COMT and TPMT
Sulphonation: SULT1A1, SULT1E1 and SULT2A1
Acetylation: NAT1 and NAT2
Glutathione: GSTM1, GSTP1 and GSTT1
Antiporter: ABCB1

Buccal cheek swab.

Collecting your samples for the genetic detoxification test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.

You need to have a break from eating and drinking at least one hour before doing the genetic detoxification test.

The genetic detoxification test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.

UK Orders

All UK orders for the genetic detoxification test include return packaging and postage for return within the UK. The package can be put in a standard post box.
It can also be sent tracked or special delivery via a post office, the fee for this is not included.

Non UK Orders

The DNA test kit is declared as a value of £4 for customs purposes. The package may be subject to customs/ import duties, for which the recipient is liable and responsible to settle.
If kits are returned due to you not accepting fees or delivery, we are sorry but the order is not refundable.International orders return packaging is provided but it is NOT prepaid. You will need to arrange and pay for the return. For returns from Europe we recommend a tracked postal service. As samples are stable it is not necessary to choose an express service.
For Non UK orders please contact [email protected] if your country is not available at the checkout.

Results for the genetic detoxification test are available in 2.5 weeks.

Your genetic detoxification test results will be emailed to you.

We are here to offer ongoing support as you progress through your health journey, regardless of your test results. Should you have any inquiries or require additional assistance we are happy to help you.

Your next steps

If you feel you need additional support in addressing your health concerns, we suggest considering collaboration with the Functional Medicine and Nutrition Consultations Clinic. (website coming soon)

Renowned for their expertise, the Functional Medicine and Nutrition Consultations Clinic comprises a team of experienced nutritional therapists and certified functional medicine practitioners who excel in addressing complex health issues.Working with genetic test results needs specialised training. Chosen carefully both Olga Hamilton and Karen Preece Smith have completed their nutrigenomics training and are ready to help you.

More information about the team of qualified functional medicine and registered Nutritional therapy practitioners that are ready to help you.

Olga Hamilton
Olga has been using DNA/genetics testing in her practice since 2015 to help her build personalised wellbeing and anti-ageing programmes. Genetic testing tells us how and where you are different from all other people, not just disease risks and predispositions, but also helps us tailor your diet and micronutrients. It is extremely helpful in personalising your diet and helps in prevention of genetic disorders.

Karen Preece Smith
Genetics and Nutrition Function Medicine:

Karen has worked with nutrigenomics since 2019. She has undertaken further training with leading UK genetic lab, Lifecode Gx, to become one of their recognised Nutrigenomic practitioners. She understands Detoxification genes well and can simplify their findings in relation to your CFS, digestive or hormonal issues as well as those issues which affect mental health and neurodiversity

As you can see Olga and Karen can help you address areas highlighted by your genetic detoxification test results, crafting a personalised plan tailored to your specific needs. This comprehensive approach would include recommendations regarding your Genetic detoxification test results and any necessary further diagnostic testing depending on your goals, supplementation, dietary adjustments, and lifestyle recommendations, all presented with clear, easy-to-follow guidance.

How to Book your appointment

We will send you details of how to book with the clinic along with your results.

How much will it cost.

£150 an hour but you will also receive a £20 off your first appointment discount code with the results.

How many sessions will I need to understand my genetic detoxification test results

Many people book a 1 hour session to go over and understand their results.And lots of people want further ongoing support as they want to address their health concerns in more details.

Which lab do you use to process the genetic detoxification test results?

We use lifecodeGX for our genetic detoxification test.

 

Is the laboratory processing my genetic methylation results accredited and reputable?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction after 5 months and completely destroyed by 6 months.

Please see the ISO Certifications below:

  • Certification to ISO 9001 for business processes;
  • Certification to ISO 13485 for the manufacturing of substances that support health care processes and systems;
  • Accreditation to ISO 17025, for laboratory testing and calibration services;
  • Compliance with Good Laboratory Practice (GLP), Good Clinical Practice (GCP), Good Distribution Practice (GDP) and current Good Manufacturing Practice (cGMP) for pharmaceutical studies and pharmaceutical related processes;
  • Accreditation to ISO 17043 for the operation and management of proficiency testing schemes;
  • Accreditation to ISO 17034 for reference material production facilities.

 

Genetic Detoxification Test

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Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.