The Melatonin Profile is a convenient, non-invasive saliva test that analyses the circadian secretion patterns of melatonin over a complete light-dark cycle. This profile can reveal abnormal levels of melatonin that relate to various physical and psychological symptoms as well as premature acceleration of the body’s ageing process.

Melatonin is a hormone that controls the daily circadian rhythm and is best known for its role in helping to initiate sleep.

It is synthesised within the pineal gland from tryptophan during the night. With its unique ability to pass through all blood barriers in the body, melatonin acts as the central hub of physiological function.

Its role is to:

• Orchestrate the complex interactions between the mind, body and environment

• Influence most of the autonomic, hormonal and behavioural functions of the human organism

• Advance sleep time and duration

• Modulate annual and circadian biorhythms (hence its ability to reduce symptoms of jet lag)

• Regulate body temperature

• Regulate cardiovascular function

• Regulate immune function, with a possible role in fighting cancer

• Act as an antioxidant

• Regulate female reproductive hormones

Melatonin’s synthesis and secretion can be strongly influenced by day length, artificial illumination, electromagnetic energy, exercise, seasonal changes, impairment in methionine metabolism and ageing. Since synthesis and secretion are easily disrupted, accurate assessment of levels and circadian rhythm is critical.

Sleep disorders


Seasonal affective disorder (SAD)

Chronic progressive multiple sclerosis

Menstrual irregularities



Saliva collected during the following times:

7:00 am to 9:00 am

3:00 pm to 5:00 pm

2:30 am to 3:30 am

Melatonin, 5-HTP and TRP may influence test results.

Do not stop medication with out consulting your GP.

One hour prior to collection do not eat, brush or floss your teeth, use mouthwash, chew gum or use any tobacco products.

You may drink ONLY water during this time.


18 years and above.

Samples must be frozen for at least 2 hours prior to returning. Samples completed on Friday –
Sunday should be stored in the freezer until Monday.

Please return via a next day service Monday – Thursday only. A courier option is sent with your test kit. You pay the laboratory directly for this test and also the return courier if you use the service. You can also make your own arrangements for returning your samples via a next day service.

10 working days.

Your test results will be emailed to you.