Genetic Oestrogen Balance Test

Test your Oestrogen Genes and support any areas that are compromised.

Genetic Oestrogen Balance Test

Test your Oestrogen Genes and support any areas that are compromised.

What is Oestrogen?

Oestrogen is one of the two main female sex hormones that helps maintain your sexual and reproductive health, along with progesterone. Oestrogen levels fluctuate throughout the menstrual cycle and declines during menopause. The primary source of oestrogen is from the ovaries and this diminishes in menopause but it will still be produced in smaller amounts from the adrenal glands and fat tissue. Men also produce oestrogen, but are significantly lower levels, and this is important for producing sperm and libido.

 

There are three major types of oestrogen:

Oestrone (E1) – Primary oestrogen that your body makes post menopause

Oestradiol (E2) – Primary form of oestrogen during the reproductive years and is the most potent.

Oestriol (E3) – Primarily produced during pregnancy and the weakest form.

Oestrogen moves around the body and will attach to areas where there are oestrogen receptors and these are broken down into two categories:

ER alpha – increases the action of oestrogen

ER beta – decreases the action of oestrogen

 

Why is Oestrogen Important?

Oestrogen main role is around growth and production of cells that are involved on the female reproductive cycle. Working with progesterone, oestrogen makes the development of secondary sex characteristics along with menstruation, pregnancy and menopause possible. During puberty, oestrogen levels rise that is needed for the development of secondary sex characteristics such as breasts and hips but also changing overall body composition. During menstruation, oestrogen is involved in ovulation and the thickening of the uterus lining, along with progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Oestrogen peaks before ovulation and thus reduces cervical mucus, making it easier to become pregnant.

 

It also has many functions outside of reproduction and is involved in cholesterol levels, bone density and muscle mass, blood sugar balance, anti-inflammatory, circulation and blood flow, brain function and collagen production.

What does the Genetic Oestrogen Test do?

The Genetic Oestrogen Test looks at your DNA to find tiny differences called SNPs, which can affect the balance of oestrogen in the body.

This test examines the genes involved in the oestrogen lifecycle. It assesses how gene variants impact the production, activation, and elimination of oestrogens. In addition, it provides details on how nutrients and environmental factors can influence oestrogen and their overall balance. The genetic oestrogen test is particularly recommended for women who suspect they have an oestrogen related conditions (detailed further below).

The report then provides personalised recommendations based on the above and how to support nutritionally to alleviate symptoms.

Who would benefit most from the Genetic Oestrogen Test?

Oestrogen imbalance underlies many health conditions, especially female health. Some of the most common are listed below:

Endometriosis

Infertility

Obesity

Breast or uterine cancer

Female sexual dysfunction (FSD)

Fibrocystic breast

Osteoporosis

Polycystic ovary syndrome (PCOS)

Primary ovarian insufficiency

Premenstrual syndrome

Uterine fibroids

Vaginal atrophy

Anorexia

 

Although most of the above are linked with females there are some symptoms for men:

Low sex drive

Erectile dysfunction and infertility

Gynecomastia – enlarged breasts in males

 

The genetic oestrogen balance report can look at genetic imbalances in these oestrogen pathways so that they can be supported.

What is being measured in the Genetic Oestrogen Test

The genetic Oestrogen Test assesses genes associated with five sub-cycles:

Synthesis: CYP17A1, CYP19A1 and SULT2A1
Activation: CYP1A1, CYP1B1 and CYP3A4
Receptors: ESR1 and ESR2
Methylation: COMT and MTHFR
Metabolism: GSTM1, GSTP1, SULT1A1, SULT1E1 and UGT1A1

What will I get with the Genetic Oestrogen Test results?

  1. Clearly illustrated and customized, color-coded genotype information .
  2. Descriptions elaborating on your gene functionality and the effects of SNP (Single Nucleotide Polymorphism).
  3. Clinically significant SNPs.
  4. Insights into nutrient and other epigenetic influences.
  5. A fully referenced report with links to research evidence.

What if I need help with the results of the Genetic Oestrogen test results?

We have a team of functional medicine practitioners and registered nutritional therapists that we can refer you to help you with your results should you need any additional support. This is not included in the cost of the test.

What happens to my DNA after the Genetic Oestrogen test?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.

The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.

At Smart Nutrition we pride ourselves in offering the best cost possible for the Genetic Oestrogen test.

 

Oestrogen imbalance underlies many health conditions, especially female health. Some of the most common are listed below:

Endometriosis

Infertility

Obesity

Breast or uterine cancer

Female sexual dysfunction (FSD)

Fibrocystic breast

Osteoporosis

Polycystic ovary syndrome (PCOS)

Primary ovarian insufficiency

Premenstrual syndrome

Uterine fibroids

Vaginal atrophy

Anorexia

 

Although most of the above are linked with females there are some symptoms for men:

Low sex drive

Erectile dysfunction and infertility

Gynecomastia – enlarged breasts in males

The genetic Oestrogen Test assesses genes associated with five sub-cycles:

Synthesis: CYP17A1, CYP19A1 and SULT2A1
Activation: CYP1A1, CYP1B1 and CYP3A4
Receptors: ESR1 and ESR2
Methylation: COMT and MTHFR
Metabolism: GSTM1, GSTP1, SULT1A1, SULT1E1 and UGT1A1

Buccal cheek swab.

Collecting your samples for the genetic oestrogen test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.

You need to have a break from eating and drinking at least one hour before doing the genetic oestrogen test.

The genetic oestrogen test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.

UK Orders

All UK orders for the genetic oestrogen test include return packaging and postage for return within the UK. The package can be put in a standard post box.
It can also be sent tracked or special delivery via a post office, the fee for this is not included.

Non UK Orders

The DNA test kit is declared as a value of £4 for customs purposes. The package may be subject to customs/ import duties, for which the recipient is liable and responsible to settle.
If kits are returned due to you not accepting fees or delivery, we are sorry but the order is not refundable.International orders return packaging is provided but it is NOT prepaid. You will need to arrange and pay for the return. For returns from Europe we recommend a tracked postal service. As samples are stable it is not necessary to choose an express service.
For Non UK orders please contact [email protected] if your country is not available at the checkout.

Results for the genetic oestrogen test are available in 2.5 weeks.

Your genetic oestrogen test results will be emailed to you.

We are here to offer ongoing support as you progress through your health journey, regardless of your test results. Should you have any inquiries or require additional assistance we are happy to help you.

Your next steps

If you feel you need additional support in addressing your health concerns, we suggest considering collaboration with the Functional Medicine and Nutrition Consultations Clinic. (website coming soon)

Renowned for their expertise, the Functional Medicine and Nutrition Consultations Clinic comprises a team of experienced nutritional therapists and certified functional medicine practitioners who excel in addressing complex health issues.Working with genetic test results needs specialised training. Chosen carefully both Olga Hamilton and Karen Preece Smith have completed their nutrigenomics training and are ready to help you.

More information about the team of qualified functional medicine and registered Nutritional therapy practitioners that are ready to help you.

Karen Preece Smith 

Methylation and Nutrition Function Medicine:
Karen has worked with nutrigenomics since 2019. She has undertaken further training with leading UK genetic lab, Lifecode Gx, to become one of their recognised Nutrigenomic practitioners. She understands Methylation genes well and can simplify their findings in relation to your CFS, digestive or hormonal issues as well as those issues which affect mental health and neurodiversity.
Olga Hamilton
Olga has been using DNA/genetics testing in her practice since 2015 to help her build personalised wellbeing and anti-ageing programmes. Genetic testing tells us how and where you are different from all other people, not just disease risks and predispositions, but also helps us tailor your diet and micronutrients. It is extremely helpful in personalising your diet and helps in prevention of genetic disorders.

As you can see Olga and Karen can help you address areas highlighted by your genetic oestrogen test results, crafting a personalised plan tailored to your specific needs. This comprehensive approach would include recommendations regarding your Genetic oestrogen test results and any necessary further diagnostic testing depending on your goals, supplementation, dietary adjustments, and lifestyle recommendations, all presented with clear, easy-to-follow guidance.

How to Book your appointment

We will send you details of how to book with the clinic along with your results.

How much will it cost.

£150 an hour but you will also receive a £20 off your first appointment discount code with the results.

How many sessions will I need to understand my genetic oestrogen test result

Many people book a 1 hour session to go over and understand their results. Lots of people want further ongoing support as they want to address their health concerns in more details.

Which lab do you use to process the genetic oestrogen test results?

We use lifecodeGX for our genetic oestrogen test.

Is the laboratory processing my genetic oestrogen results accredited and reputable?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction after 5 months and completely destroyed by 6 months.

Please see the ISO Certifications below:

  • Certification to ISO 9001 for business processes;
  • Certification to ISO 13485 for the manufacturing of substances that support health care processes and systems;
  • Accreditation to ISO 17025, for laboratory testing and calibration services;
  • Compliance with Good Laboratory Practice (GLP), Good Clinical Practice (GCP), Good Distribution Practice (GDP) and current Good Manufacturing Practice (cGMP) for pharmaceutical studies and pharmaceutical related processes;
  • Accreditation to ISO 17043 for the operation and management of proficiency testing schemes;
  • Accreditation to ISO 17034 for reference material production facilities.

Genetic Oestrogen Balance Test

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Test your Detoxification Genes and support any areas that are compromised.

Test your adrenal and sex hormones with the benefit of additional organic acid markers and your Cortisol Awakening Response tested. This will give you a comprehensive overview so that you can support any imbalances.

 

PUT YOURSELF to the TEST

Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.