Genetic Thyroid Test

Test your genes involved in the thyroid and support any areas that are compromised.

Genetic Thyroid Test

Test your genes involved in the thyroid and support any areas that are compromised.

What is your Thyroid?

The thyroid is an endocrine gland that is situated in the neck and is involved in the metabolism of every cell in the body. Your thyroid produces and releases the following hormones:

 

  • Thyroxine (T4) – the main hormone that your thyroid makes, around 90%,  but this is not the active form and the body needs to convert this to T3 for this to have an effect on your metabolism. The conversion process is called deiodination.
  • Triiodothyronine (T3) – Your body produces a much smaller amount of this, around 9%,  but this is the active form that influences metabolism. The conversion of T4 to T3 is a key thyroid pathway.
  • Reverse Triiodothyronine (RT3) – this reverses the effect of T3 and the body makes small amounts of this.
  • Calcitonin – this hormone is responsible for regulating the amount of calcium in the blood.

 

Why is your Thyroid Important?

When the thyroid isn’t working properly, it can impact the entire body as all your cells need energy to function and the thyroid is responsible for controlling the speed of your metabolism.

 

Complications can happen when the thyroid either speeds up or slows down; with  hyperthyroidism (overactive thyroid) or hypothyroidism (underactive thyroid) presenting. In addition, thyroid autoimmunity, such as Graves and Hashimoto’s, or imbalance in the Hypothalamus-Pituitary-Thyroid (HPT) axis and thyroid cancers all have an impact on the thyroid. All of these factors will influence the transportation, activation and response within the body to thyroid hormones.

 

A well functioning thyroid is essential to the following systems:

 

Cardiovascular system – the thyroid helps regulate the heartbeat, rate and strength, controlling the amount of blood that is pumped around the body.

Nervous system – thyroid hormones can influence both the development and function of both the peripheral and central nervous system

Digestive system – involved in how food moves through your system

Reproductive system – Good thyroid hormone production is essential for fertility and regular menstruation.

 

Thyroid hormone production is sensitive to genetic and environmental factors. Nutrients that have a direct effect on the thyroid include tyrosine, selenium and iodine, along with a host of co-factors. Toxins that can really impact thyroid function include fluoride, moulds or chlorine. Bacteria and viruses can impact and also lifestyle factors and stressors.

What does the Genetic Thyroid Test do?

The Genetic Thyroid Test looks at your DNA to find tiny differences called SNPs, which can affect the thyroid hormone lifecycle.

It looks at the genes involves in synthesis within the thyroid, activation in peripheral tissues, transport, and metabolism. It also evaluates the processing of cofactors such as vitamins D and A, as well as inhibitors like stress and toxins. Additionally, the report examines genes that may increase susceptibility to inflammation and autoimmunity.

 

Who would benefit most from the Genetic Thyroid Test?

If your thyroid is not functioning effectively then it can increase susceptibility to various health conditions. Thyroid problems are becoming very common and genetically women are 5 to 8 times more likely to be affected.

Thyroid conditions can be split into primary or secondary. Primary is when the thyroid gland is directly impacted and secondary, when the pituitary gland is effected and this influences the amount of thyroid-stimulating hormone (TSH) that is produced.

Symptoms can be grouped to whether it is linked with over or under production.

Hypothyroidism (underactive thyroid) – Fatigue, weight gain, cold extremities, cold intolerance, constipation, depression, dry skin and low libido.

Hyperthyroidism (overactive thyroid) – heart palpitations, anxiety, heat intolerance, insomnia and weight loss.

If you have been diagnosed with an autoimmune condition then understanding genetic thyroid factors is useful.

 

What is being measured in the Genetic Thyroid Test

The genetic thyroid test assesses genes associated with the sub-cycles below:

HPT Axis: CAPZB, FKBP5, GPX1*, PDE8B, TG*, TSHR* (*also involved in autoimmunity)
Autoimmune: CTLA4, FOXE1, HLA-DQA1, HLA-DQB1 and PTPN22
Inflammation: CD40, FCRL3, IL6, TNF, GC and VDR
Transport: SLCO1B1 and SLCO1C1
Activation: DIO1, DIO2, BCO1, GC and VDR
Metabolism: SULT1A1, SULT1E1, UGT1A1

What will I get with the Genetic Thyroid test results?

  1. Clearly illustrated and customized, color-coded genotype information .
  2. Descriptions elaborating on your gene functionality and the effects of SNP (Single Nucleotide Polymorphism).
  3. Clinically significant SNPs.
  4. Insights into nutrient and other epigenetic influences.
  5. A fully referenced report with links to research evidence.

What if I need help with the results of the Genetic Thyroid test results?

We have a team of functional medicine practitioners and registered nutritional therapists that we can refer you to help you with your results should you need any additional support. This is not included in the cost of the test.

What happens to my DNA after the Genetic Thyroid test?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction at 5 months and completely destroyed by 6 months.

The client report, the data and the DNA sample is never (and will never be) shared with, or sold to third parties. All of the data extraction and analysis is done in the UK.

At Smart Nutrition we pride ourselves in offering the best cost possible for the Genetic Thyroid test.

 

Thyroid imbalance presents with many symptoms  and have been associated with many clinical conditions including, but not limited to:

Fatigue

Weight gain

Cold extremities or intolerance

Constipation

Depression

Dry skin

Low libido

Heart palpitations

Anxiety

Heat intolerance

Insomnia

Weight loss

 

The symptoms will relate to whether the thyroid is under or over producing.

The genetic thyroid test assesses genes associated with the sub-cycles below:

HPT Axis: CAPZB, FKBP5, GPX1*, PDE8B, TG*, TSHR* (*also involved in autoimmunity)
Autoimmune: CTLA4, FOXE1, HLA-DQA1, HLA-DQB1 and PTPN22
Inflammation: CD40, FCRL3, IL6, TNF, GC and VDR
Transport: SLCO1B1 and SLCO1C1
Activation: DIO1, DIO2, BCO1, GC and VDR
Metabolism: SULT1A1, SULT1E1, UGT1A1

Buccal cheek swab.

Collecting your samples for the genetic thyroid test is simple, it is a non invasive cheek swab and is suitable for all ages as long as a cheek swab can be collected.

You need to have a break from eating and drinking at least one hour before doing the genetic thyroid test.

The genetic thyroid test is available for anyone, including children, with the consent of a parent or guardian. When testing a child under 18, parental consent is required.

UK Orders

All UK orders for the genetic histamine intolerance test include return packaging and postage for return within the UK. The package can be put in a standard post box.
It can also be sent tracked or special delivery via a post office, the fee for this is not included.

Non UK Orders

The DNA test kit is declared as a value of £4 for customs purposes. The package may be subject to customs/ import duties, for which the recipient is liable and responsible to settle.
If kits are returned due to you not accepting fees or delivery, we are sorry but the order is not refundable.International orders return packaging is provided but it is NOT prepaid. You will need to arrange and pay for the return. For returns from Europe we recommend a tracked postal service. As samples are stable it is not necessary to choose an express service.
For Non UK orders please contact [email protected] if your country is not available at the checkout.

Results for the genetic thyroid test are available in 2.5 weeks.

Your genetic thyroid test results will be emailed to you.

We are here to offer ongoing support as you progress through your health journey, regardless of your test results. Should you have any inquiries or require additional assistance we are happy to help you.

Your next steps

If you feel you need additional support in addressing your health concerns, we suggest considering collaboration with the Functional Medicine and Nutrition Consultations Clinic. (website coming soon)

Renowned for their expertise, the Functional Medicine and Nutrition Consultations Clinic comprises a team of experienced nutritional therapists and certified functional medicine practitioners who excel in addressing complex health issues.Working with genetic test results needs specialised training. Chosen carefully both Olga Hamilton and Karen Preece Smith have completed their nutrigenomics training and are ready to help you.

More information about the team of qualified functional medicine and registered Nutritional therapy practitioners that are ready to help you.

Karen Preece Smith 

Methylation and Nutrition Function Medicine:
Karen has worked with nutrigenomics since 2019. She has undertaken further training with leading UK genetic lab, Lifecode Gx, to become one of their recognised Nutrigenomic practitioners. She understands thyroid genes well and can simplify their findings in relation to your CFS, digestive or hormonal issues as well as those issues which affect mental health and neurodiversity.
Olga Hamilton
Olga has been using DNA/genetics testing in her practice since 2015 to help her build personalised wellbeing and anti-ageing programmes. Genetic testing tells us how and where you are different from all other people, not just disease risks and predispositions, but also helps us tailor your diet and micronutrients. It is extremely helpful in personalising your diet and helps in prevention of genetic disorders.

As you can see Olga and Karen can help you address areas highlighted by your genetic thyroid test results, crafting a personalised plan tailored to your specific needs. This comprehensive approach would include recommendations regarding your Genetic thyroid test results and any necessary further diagnostic testing depending on your goals, supplementation, dietary adjustments, and lifestyle recommendations, all presented with clear, easy-to-follow guidance.

How to Book your appointment

We will send you details of how to book with the clinic along with your results.

How much will it cost.

£150 an hour but you will also receive a £20 off your first appointment discount code with the results.

How many sessions will I need to understand my genetic thyroid test result

Many people book a 1 hour session to go over and understand their results.And lots of people want further ongoing support as they want to address their health concerns in more details.

Which lab do you use to process the genetic thyroid test results?

We use lifecodeGX for our genetic detoxification test.

 

Is the laboratory processing my genetic thyroid results accredited and reputable?

Each test is processed in an ISO certified UK laboratory and all samples are completely destroyed after 3 months. All client genotyping data is marked for destruction after 5 months and completely destroyed by 6 months.

Please see the ISO Certifications below:

  • Certification to ISO 9001 for business processes;
  • Certification to ISO 13485 for the manufacturing of substances that support health care processes and systems;
  • Accreditation to ISO 17025, for laboratory testing and calibration services;
  • Compliance with Good Laboratory Practice (GLP), Good Clinical Practice (GCP), Good Distribution Practice (GDP) and current Good Manufacturing Practice (cGMP) for pharmaceutical studies and pharmaceutical related processes;
  • Accreditation to ISO 17043 for the operation and management of proficiency testing schemes;
  • Accreditation to ISO 17034 for reference material production facilities.

Genetic Thyroid Test

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PUT YOURSELF to the TEST

Please do not return samples to the laboratories that may arrive after Wednesday 27th March and up to and including Monday 2nd April.

The laboratories are closed from the 28th March – 2nd April for the Easter Holiday.